Diffuse thyrotoxic goiter, Exophthalmic Goiter
(Graves' Disease or Basedow's Disease)
Graves' disease occurs when the immune system mistakenly attacks the thyroid gland and causes it to overproduce a hormone called thyroxine. This abnormal immune response can also affect the tissue behind the eyes as well as the skin. Because thyroxine regulates the cell's metabolism, an excess of this hormone in the bloodstream can increase the basal metabolic rate by 60 to 100 %.
Graves' disease is the most common cause of hyperthyroidism. It usually affects women in their twenties, but the disorder may occur at any age and may affect men as well. The female to male ratio is 8:1. In the USA, the incidence is about 5 in 10,000 people.
Exophthalmos (Protruding eyes)
Tachycardia, irregular heart beat and palpitations
Breast enlargement in men (possible)
Frequent bowel movements
Menstrual irregularities in women