Rapidly growing Merkel Cell Carcinoma of the face in an elderly man.
Merkel cell carcinoma (MCC), or neuroendocrine carcinoma of the skin, is an uncommon and often aggressive malignancy that has a poor prognosis. The Merkel cell is located in or near the basal layer of the epidermis and is closely associated with terminal axons. MCC is predominantly a tumor of the elderly, and most reported cases have occurred in Caucasians. It occurs most frequently in the head and neck region and in the extremities, and has a predilection for the periocular region.